作为一部兼具学术底色的普及读物,《法律深处是人心》蕴含深厚的历史知识与法学理论。书中所引案例,囊括了中华法系具有代表性的制度、思想与文化,阐扬了民惟邦本、明德慎罚、德主刑辅、隆礼重法等区别于其他法系的独特文化标识。如在东汉“孙章矫诏案”中,中常侍孙章将兄弟共同犯罪、重判兄长的诏令错念成重判兄弟两人,导致弟弟被误杀,按律构成“矫诏”罪,当处腰斩。但律学家郭躬从“君子原心”的古训出发,强调审案需探究动机,主张孙章属于过失犯罪,建议依律判处罚金,最终汉明帝认可其建议,连连称“善”。这种审慎态度,彰显了中华法系“明德慎罚”的人本主义色彩。
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Another way to look at our threshold matrix is as a kind of probability matrix. Instead of offsetting the input pixel by the value given in the threshold matrix, we can instead use the value to sample from the cumulative probability of possible candidate colours, where each colour is assigned a probability or weight . Each colour’s weight represents it’s proportional contribution to the input colour. Colours with greater weight are then more likely to be picked for a given pixel and vice-versa, such that the local average for a given region should converge to that of the original input value. We can call this the N-candidate approach to palette dithering.
对于一些既往的热门赛道,比如GLP-1,最终能脱颖而出的仍将会是少数企业,决定因素是临床效果。尚未上市的产品必须要找到差异化优势:一是给药形式优化,不少人都会在意注射带来的疼痛和不便,所以口服剂型仍有空间;二是疗效,特别是减重效果、心血管获益等;三是给药频率,半衰期更长、给药频次更低的产品更有机会;四是长期安全性,降低不良反应,减少停药反弹等。